Mar 18, 2015 · Here we demonstrate that a single naturally occurring 2’-O-methylation within a synthetic 18s rRNA derived RNA sequence prevents IFN-α production, however secretion of proinflammatory …

2'- O -methyl-adenosine, a modified adenosine. 2'-O-methylation (2'-O-Me) is a nucleotide epitranscriptomics modification commonly found in ribosomal RNA (rRNA), transfer RNA (tRNA), and …

Aug 8, 2018 · Immunostimulation decreases from Cm to Gm, suggesting that the binding site is suited to optimally recognize features of a purine residue, and of course the 2′-O-methyl group.

Martin described a robust route to 2’-O-alkylribonucleosides in which the ribose 2’-OH group is substituted with 2’-ethylene glycol derivatives. Oligonucleotides containing these modifications …

Apr 1, 2023 · The consequences of such methylations are still puzzling since they were associated with both proviral and antiviral effects. Here, we focus on the mechanisms governing vRNA 2′-O …

We show that engineering of the gate to reduce steric bulk in the context of a previously described RNA polymerase activity unlocks the synthesis of 2′-modified RNA oligomers, specifically the ...

Oct 13, 2021 · SSOs using 2′-O-methyl RNA (2OMe) chemistry designed to restore dystrophin were the first oligonucleotides tested in DMD (Cirak et al., 2011). However, they failed at trials due to only a …

Feb 5, 2019 · Nm (2′-O-methylation) is one of the most common modifications in the RNA world. It has the potential to influence the RNA molecules in multiple ways, such as structure, stability, and …

Feb 29, 2024 · Background Oligonucleotide therapeutics have emerged as a promising and dynamic class of pharmaceutical agents with remarkable potential for treating a wide spectrum of genetic and …

Mar 5, 2020 · 61 Cap 1 2’O methylation can further enhance this translation (8, 10, 11). mRNA cap 2’O 62 methylation has also been shown to prevent degradation of modified transcripts by 63 …